Kieran Trippier (groin) and Davinson Sanchez (hamstring) were both ruled out of Gameweek 13 by Mauricio Pochettino in his pre-match press conference on Thursday, with Trippier aiming to return to training in time for the north London derby the week after.
Sanchez, however, will likely be out for a month at least. Jan Vertonghen (hamstring) has made a timely return to fitness and has trained with the squad in the build-up to the visit of Chelsea on Saturday evening, but Pochettino said the Belgian centre-back will still have to be assessed before kick-off.
Juan Foyth could very well continue in the back four regardless, with Serge Aurier surely set to deputise for Trippier.
The Spurs boss said his Argentinean trio of Foyth, Paulo Gazzaniga and Erik Lamela only arrived in the UK in the early hours of Thursday morning, so their lengthy trans-Atlantic flight might come into his thinking too.
Pochettino discussed that the club carefully managed Christian Eriksen’s recovery before the international break with his minutes for Denmark in mind and the midfielder could come into the reckoning at the expense of Lamela.
Although although Harry Winks could instead bolster the engine room given that the Lilywhites will be up against Chelsea’s midfield three on Saturday.
Eric Dier may have to fight it out with Victor Wanyama for the shielding role, meanwhile.
Mousa Dembele (ankle) is a long-term absentee, while Danny Rose (groin) is in the final stages of his rehabilitation and come back into contention for the match against Arsenal in Gameweek 14.Follow Football News Arena on Facebook and Twitter for the latest transfer news, injury news, team news and rumours from across the major Leagues in Europe and around the World.