Slaven Bilic will be without Diafra Sakho for the trip to Old Trafford, with the Senegal international likely to be ruled out for around two months with the thigh injury he suffered in the 1-1 draw against West Brom.
Andy Carroll should earn a recall to the starting XI then, while Mauro Zarate’s goal against the Baggies is set to cement his start alongside Manuel Lanzini and Victor Moses in the three attacking midfield positions in the Croatian’s favoured 4-5-1 system.
Michail Antonio and Nikica Jelavic provide back-up in the attacking areas. Mark Noble will be available again after serving a one-match ban: he is likely to replace Pedro Obiang alongside Cheikhou Kouyate at the base of midfield.
Angelo Ogbonna earned a recall last weekend at centre-back, and could continue to get the nod ahead of James Tomkins, with Winston Reid, Carl Jenkinson and Aaron Creswell expected to make up the rest of the back four in front of Adrian in goal.
James Collins is also available again after completing his three-match suspension. Enner Valencia is a few weeks away from returning to first-team action, while Dimitri Payet remains out.