Marcos Rojo faces an extended spell on the sidelines after dislocating a shoulder in training, whilst Wayne Rooney is also ruled out with an ankle problem sustained against Leicester last weekend.
With his options up top limited, Louis van Gaal could return to a 4-2-3-1 system, having trialled a 3-4-1-2 last weekend.
Jesse Lingard has been passed fit and could reclaim the left flank role, though Memphis Depay is also in contention, with the Dutchman also capable of playing centrally behind Anthony Martial.
At the back, Paddy McNair appears likeliest to miss out should United revert to a four-man defence.
Morgan Schneiderlin is pushing for a recall alongside Bastian Schweinsteiger at the base of the midfield, though Michael Carrick will hope to retain his start against the Hammers.
Luke Shaw, Phil Jones and Antonio Valencia are all out, while Ander Herrera remains sidelined after picking up a hamstring problem against Watford.Facebook and Twitter for the latest transfer news, injury news, team news and rumours from across the major Leagues in Europe and around the World.