Louis van Gaal made three changes for the visit of West Ham to Old Trafford last weekend, with Marouane Fellaini coming in for the injured Wayne Rooney, while Morgan Schneiderlin and the fit-again Jesse Lingard replaced Michael Carrick and Ashley Young.
Van Gaal also reverted to a 4-2-3-1 formation, after an experiment with 3-4-1-2 at Leicester. Ahead of the trip to Bournemouth, Chris Smalling and Matteo Darmian have been ruled out after sustaining groin and hamstring injuries respectively following the midweek champions league exit to Wolfsburg.
Van Gaal could turn to Paddy McNair to partner Daley Blind in defence, while youngsters Guillermo Varela and Cameron Borthwick-Jackson may occupy the full-back berths, though Ashley Young offers an alternative here.
Bastian Schweinsteiger serves the first of a three-match ban following an FA charge for violent conduct, though Morgan Schneiderlin has recovered from a minor hip problem in time for the weekend.
In attack, Wayne Rooney remains sidelined with an ankle injury, which should see Anthony Martial lead the line. Juan Mata, Memphis Depay and Jesse Lingard appear in pole position for the three attacking midfield spots behind Martial, though Young is again an option here.
Luke Shaw, Phil Jones, Marcos Rojo and Antonio Valencia are all out, while Ander Herrera remains sidelined with a hamstring problem.